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1.
Braz. J. Anesth. (Impr.) ; 73(6): 794-809, Nov.Dec. 2023. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1520384

RESUMO

Abstract Background: This study compares Fascia Iliaca compartment (FI) block and Pericapsular Nerve Group (PENG) block for hip surgery. Methods: Pubmed, Embase and Cochrane were systematically searched in April 2022. Inclusion criteria were: Randomized Controlled Trials (RCTs); comparing PENG block versus FI block for hip surgery; patients over 18 years of age; and reporting outcomes immediately postoperative. We excluded studies with overlapped populations and without a head-to-head comparison of the PENG block vs. FI block. Mean-Difference (MD) with 95% Confidence Intervals (CI) were pooled. Trial Sequential Analyses (TSA) were performed to assess inconsistency. Quality assessment and risk of bias were performed according to Cochrane recommendations. Results: Eight RCTs comprising 384 patients were included, of whom 196 (51%) underwent PENG block. After hip surgery, PENG block reduced static pain score at 12h post-surgery (MD = 0.61 mm; 95% CI 1.12 to -0.09; p = 0.02) and cumulative postoperative oral morphine consumption in the first 24h (MD = -6.93 mg; 95% CI -13.60 to -0.25; p = 0.04) compared with the FI group. However, no differences were found between the two techniques regarding dynamic and static pain scores at 6 h or 24 h post-surgery, or in the time to the first analgesic rescue after surgery. Conclusion: The findings suggest that PENG block reduced opioid consumption in the first 24 h after surgery and reduced pain scores at rest at 12 h post-surgery. Further research is needed to fully understand the effects of the PENG block and its potential benefits compared to FI block. PROSPERO registration: CRD42022339628 PROSPERO registration: https://www.crd.york.ac.uk/prospero/display_record.php? RecordID=339628


Assuntos
Humanos , Adolescente , Adulto , Nervo Femoral , Bloqueio Nervoso/métodos , Dor Pós-Operatória/prevenção & controle , Dor Pós-Operatória/tratamento farmacológico , Ensaios Clínicos Controlados Aleatórios como Assunto , Fáscia/lesões
2.
Nature ; 623(7988): 792-802, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37968392

RESUMO

Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of tissue inflammation, contraction and scar formation1. Here we identify a multipotent fibroblast progenitor marked by CD201 expression in the fascia, the deepest connective tissue layer of the skin. Using skin injury models in mice, single-cell transcriptomics and genetic lineage tracing, ablation and gene deletion models, we demonstrate that CD201+ progenitors control the pace of wound healing by generating multiple specialized cell types, from proinflammatory fibroblasts to myofibroblasts, in a spatiotemporally tuned sequence. We identified retinoic acid and hypoxia signalling as the entry checkpoints into proinflammatory and myofibroblast states. Modulating CD201+ progenitor differentiation impaired the spatiotemporal appearances of fibroblasts and chronically delayed wound healing. The discovery of proinflammatory and myofibroblast progenitors and their differentiation pathways provide a new roadmap to understand and clinically treat impaired wound healing.


Assuntos
Receptor de Proteína C Endotelial , Fáscia , Cicatrização , Animais , Camundongos , Diferenciação Celular , Hipóxia Celular , Linhagem da Célula , Modelos Animais de Doenças , Receptor de Proteína C Endotelial/metabolismo , Fáscia/citologia , Fáscia/lesões , Fáscia/metabolismo , Fibroblastos/citologia , Fibroblastos/metabolismo , Perfilação da Expressão Gênica , Inflamação/metabolismo , Inflamação/patologia , Miofibroblastos/citologia , Miofibroblastos/metabolismo , Transdução de Sinais , Análise da Expressão Gênica de Célula Única , Pele/citologia , Pele/lesões , Pele/metabolismo , Tretinoína/metabolismo
3.
Foot Ankle Int ; 42(3): 251-256, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33106030

RESUMO

BACKGROUND: The deep deltoid ligament (DDL) is a key stabilizer to the medial ankle and ankle mortise and can be disrupted in ligamentous supination external rotation type IV (LSER4) ankle fractures. The purpose of this study was to define the medial clear space (MCS) measurement on injury mortise radiographs that corresponds with complete DDL injury. METHODS: A retrospective record review at a level 1 hospital was performed identifying patients with LSER4 ankle fractures who underwent arthroscopy and open reduction internal fixation. Chart reviews provided arthroscopic images and operative reports. Complete DDL injury was defined as arthroscopic visualization of the posterior tibial tendon (PTT). Inability to completely visualize the PTT was defined as a partial DDL injury. MCS was measured on injury mortise radiographs. Eighteen subjects met inclusion criteria. RESULTS: Twelve subjects had complete and 6 subjects had partial DDL injury based on arthroscopic findings. Patients with complete DDL injury and those with partial DDL injury had injury radiograph MCS ranging from 5.5 to 29.9 mm and 4.0 to 5.0 mm, respectively. All patients with MCS ≥5.5 mm on injury radiographs had complete DDL injury and all patients with MCS ≤5.0 mm on injury radiographs had partial DDL injury. CONCLUSION: Complete DDL injury was found on injury ankle mortise radiographs as MCS widening of ≥5.5 mm, which correlated with arthroscopic visualization of the PTT. Using this cutoff, surgeons can surmise the presence of a complete deltoid ligament injury, allowing for improved preoperative planning. LEVEL OF EVIDENCE: Level III, retrospective comparative study.


Assuntos
Fraturas do Tornozelo/diagnóstico por imagem , Traumatismos do Tornozelo/diagnóstico por imagem , Ligamentos Articulares/lesões , Radiografia/métodos , Artroscopia/métodos , Fáscia/lesões , Humanos , Amplitude de Movimento Articular/fisiologia , Estudos Retrospectivos , Rotação , Supinação
4.
J Plast Reconstr Aesthet Surg ; 74(6): 1203-1212, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33268043

RESUMO

BACKGROUND: We present a comparative series to utilize minimally invasive endoscopic, total extraperitoneal laparoscopic (TEP-lap), and transabdominal preperitoneal robotic perforator (TAP-RAP) harvest of the deep inferior epigastric (DIE) vessels for autologous breast reconstruction (ABR) to mitigate donor site morbidity. We hypothesized that TEP-lap and TAP-RAP harvests of abdominal-based free flaps are safe techniques associated with decreased fascial incision when compared with the endoscopic harvest. METHODS: We designed a retrospective cohort series of subjects with newly diagnosed breast cancer who presented for ABR using endoscopic (control), laparoscopic, or robotic assistance between September 2017 and April 2019. The primary outcome variables were flap success (i.e., absence of perioperative flap loss), fascial incision length, and intraoperative complications. Secondary variables included operating time, costs, and postoperative complications within 90 days (arterial thrombosis, venous congestion, bulge/hernia, and operative revision). Exclusion criteria included < 90 days follow-up. RESULTS: In total 94, 38, and 3 subjects underwent endoscopic, TEP-lap, and TAP-RAP flap harvests. Mean lengths of fascial incisions for the endoscopic and laparoscopic cohorts were 4.5 ±â€¯0.5 cm and 2.0 ±â€¯0.6 cm (p < 0.0001), while incision length depended on the concurrent procedure in the robotic cohort. No subjects required conversion to an open harvest. There were no bleeding complications, intra-abdominal injuries, flap losses, or abdominal bulges/hernias noted in the TEP-lap and TAP-RAP cohorts. CONCLUSION: Minimally invasive DIEP flap harvest may decrease fascial injury when compared with conventional open harvest. There are significant trade-offs among harvest methods. TEP-lap harvest may better balance the trade-off related to abdominal wall morbidity.


Assuntos
Músculos Abdominais , Complicações Intraoperatórias/prevenção & controle , Laparoscopia , Mamoplastia , Complicações Pós-Operatórias , Procedimentos Cirúrgicos Robóticos , Músculos Abdominais/irrigação sanguínea , Músculos Abdominais/transplante , Autoenxertos , Neoplasias da Mama/cirurgia , Artérias Epigástricas/cirurgia , Fáscia/lesões , Feminino , Humanos , Laparoscopia/efeitos adversos , Laparoscopia/métodos , Mamoplastia/efeitos adversos , Mamoplastia/métodos , Pessoa de Meia-Idade , Retalho Perfurante/transplante , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/etiologia , Estudos Retrospectivos , Procedimentos Cirúrgicos Robóticos/efeitos adversos , Procedimentos Cirúrgicos Robóticos/métodos , Coleta de Tecidos e Órgãos/efeitos adversos , Coleta de Tecidos e Órgãos/métodos
5.
Medicine (Baltimore) ; 99(46): e23201, 2020 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-33181700

RESUMO

OBJECTIVES: Prolotherapy or proliferative therapy is a treatment option for damaged connective tissues involving the injection of a solution (proliferant) which theoretically causes an initial cell injury and a subsequent "proliferant" process of wound healing via modulation of the inflammatory process. Nonetheless, the benefits of dextrose prolotherapy have not been adequately evaluated. Therefore, the present study assesses the effectiveness and superiority of prolotherapy separately in treating dense fibrous connective tissue injuries. METHODS: PubMed, Scopus, and Embase were searched from the earliest record to February 18, 2019. This study included randomized controlled trials whichBoth analysis at individual studies level and pooled meta-analysis were performed. RESULTS: Ten trials involving 358 participants were included for review. At study level, the majority of comparisons did not reveal significant differences between dextrose prolotherapy and no treatment (or placebo) regarding pain control. The meta-analysis showed dextrose prolotherapy was effective in improving activity only at immediate follow-up (i.e., 0-1 month) (standardized mean difference [SMD]: 0.98; 95% confidence interval [CI]: 0.40-1.50; I = 0%); and superior to corticosteroid injections only in pain reduction at short-term follow-up (i.e., 1-3 month) (SMD: 0.70; 95% CI: 0.14-1.27; I = 51%). No other significant SMDs were found in this analysis. CONCLUSIONS: There is insufficient evidence to support the clinical benefits of dextrose prolotherapy in managing dense fibrous tissue injuries. More high-quality randomized controlled trials are warranted to establish the benefits of dextrose prolotherapy. REVIEW REGISTRATION: PROSPERO (CRD42019129044).


Assuntos
Fáscia , Glucose , Ligamentos , Proloterapia , Tendinopatia , Humanos , Fáscia/efeitos dos fármacos , Fáscia/lesões , Glucose/administração & dosagem , Glucose/uso terapêutico , Ligamentos/efeitos dos fármacos , Ligamentos/lesões , Proloterapia/instrumentação , Proloterapia/métodos , Tendinopatia/tratamento farmacológico
6.
Nat Commun ; 11(1): 5653, 2020 11 06.
Artigo em Inglês | MEDLINE | ID: mdl-33159076

RESUMO

Scars are more severe when the subcutaneous fascia beneath the dermis is injured upon surgical or traumatic wounding. Here, we present a detailed analysis of fascia cell mobilisation by using deep tissue intravital live imaging of acute surgical wounds, fibroblast lineage-specific transgenic mice, and skin-fascia explants (scar-like tissue in a dish - SCAD). We observe that injury triggers a swarming-like collective cell migration of fascia fibroblasts that progressively contracts the skin and form scars. Swarming is exclusive to fascia fibroblasts, and requires the upregulation of N-cadherin. Both swarming and N-cadherin expression are absent from fibroblasts in the upper skin layers and the oral mucosa, tissues that repair wounds with minimal scar. Impeding N-cadherin binding inhibits swarming and skin contraction, and leads to reduced scarring in SCADs and in animals. Fibroblast swarming and N-cadherin thus provide therapeutic avenues to curtail fascia mobilisation and pathological fibrotic responses across a range of medical settings.


Assuntos
Cicatriz/metabolismo , Fáscia/lesões , Fibroblastos/metabolismo , Ferimentos e Lesões/metabolismo , Adulto , Idoso , Animais , Caderinas/metabolismo , Movimento Celular , Cicatriz/fisiopatologia , Fáscia/citologia , Fáscia/metabolismo , Feminino , Fibroblastos/citologia , Humanos , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Pessoa de Meia-Idade , Pele/citologia , Pele/lesões , Pele/metabolismo , Pele/fisiopatologia , Cicatrização , Ferimentos e Lesões/fisiopatologia , Adulto Jovem
7.
Eur J Pharmacol ; 880: 173169, 2020 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-32416184

RESUMO

Chronic opioids treatment is impeded by the development of analgesic tolerance and opioid-induced hyperalgesia. Recent studies have shown that multi-functional opioid compounds produce analgesic activities with limited side effects. We developed a novel multi-functional peptide targeting opioid and neuropeptide FF receptors named BN-9, which produced potent and non-tolerance forming antinociceptive effect after supraspinal and systemic administrations. In the present study, the analgesic properties and potential side effects of intrathecal BN-9 were investigated in a range of preclinical rodent models. In complete Freund's adjuvant-induced inflammatory pain model, intrathecal BN-9 dose-dependently produced analgesic effect via opioid receptors, and the spinal antinociceptive effect was augmented by the neuropeptide FF receptor antagonist RF9. In contrast, in plantar incision-induced postoperative pain model, BN-9 exhibited potent anti-allodynic effect via opioid receptors and, at least partially, neuropeptide FF receptors. In mouse models of acetic acid-induced visceral pain and formalin pain, BN-9-induced spinal antinociception was mainly mediated by opioid receptors, independent of neuropeptide FF receptors. Furthermore, at the spinal level, chronic treatments with BN-9 did not lead to analgesic tolerance and cross-tolerance to morphine. Moreover, opioid-induced hyperalgesia was observed after repeated administration of morphine, but not BN-9. Taken together, our present study suggests that intrathecal BN-9 produces potent and non-tolerance forming antinociception, and does not cause opioid-induced hyperalgesia. Thus, BN-9 might serve as a promising lead compound in the development of multi-functional opioid analgesics with minimized side effects.


Assuntos
Analgésicos Opioides/uso terapêutico , Oligopeptídeos/agonistas , Oligopeptídeos/uso terapêutico , Dor/tratamento farmacológico , Ácido Acético , Analgésicos Opioides/efeitos adversos , Animais , Tolerância a Medicamentos , Fáscia/lesões , Formaldeído , Temperatura Alta/efeitos adversos , Hiperalgesia/induzido quimicamente , Injeções Espinhais , Masculino , Camundongos , Morfina/efeitos adversos , Morfina/uso terapêutico , Dor/etiologia , Ratos Wistar
8.
J Athl Train ; 55(2): 181-187, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31895592

RESUMO

CONTEXT: Researchers analyzing data from the National Collegiate Athletic Association Injury Surveillance Program have not considered the differences in foot injuries across specific sports and between males and females. OBJECTIVE: To describe the epidemiologic differences in rates of overall foot injuries and common injuries among sports and between sexes. DESIGN: Descriptive epidemiology study. SETTING: Online injury-surveillance data from 15 unique sports involving males and females that demonstrated 1967 injuries over 4 821 985 athlete-exposures. PATIENTS OR OTHER PARTICIPANTS: Male and female athletes competing in National Collegiate Athletic Association sports from the 2009-2010 through 2014-2015 seasons. MAIN OUTCOME MEASURE(S): Foot injury rates (per 10 000 athlete-exposures) and the proportion of foot injuries were calculated for each sport. The effect of sex was calculated using Poisson-derived confidence intervals for 8 paired sports. A risk analysis was performed using a 3 × 3 quantitative injury risk-assessment matrix based on both injury rate and mean days of time loss. RESULTS: Foot injury rates differed between sports, with the highest rates in female gymnastics, male and female cross-country, and male and female soccer athletes. Cross-country and track and field had the highest proportions of foot injuries for both female and male sports. The 5 most common injuries were foot/toe contusions, midfoot injuries, plantar fascia injuries, turf toe, and metatarsal fractures. Only track and field athletes demonstrated a significant sex difference in injury rates, with female athletes having the higher rate. The quantitative injury risk-assessment matrix identified the 4 highest-risk injuries, considering both rate and severity, as metatarsal fractures, plantar fascia and midfoot injuries, and foot/toe contusions. CONCLUSIONS: Important differences were present among sports in terms of injury rates, the most common foot injuries, and the risk (combination of frequency and severity) of injury. These differences warrant further study to determine the mechanisms of injury and target intervention efforts.


Assuntos
Traumatismos em Atletas/epidemiologia , Traumatismos do Pé/epidemiologia , Traumatismos do Tornozelo/epidemiologia , Contusões/epidemiologia , Fáscia/lesões , Feminino , Fraturas Ósseas/epidemiologia , Ginástica/lesões , Humanos , Incidência , Masculino , Metatarso/lesões , Estações do Ano , Distribuição por Sexo , Futebol/lesões , Atletismo/lesões , Estados Unidos/epidemiologia , Universidades , Adulto Jovem
9.
Knee Surg Sports Traumatol Arthrosc ; 28(3): 969-974, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31270589

RESUMO

PURPOSE: The purpose of this study was to map saphenous nerve injuries after gracilis tendon harvest, with the aim of contributing knowledge that makes it possible to prevent these injuries. METHODS: Twenty-two cadaver limbs were used. Three were dissected to examine fascial structures between the saphenous nerve and the gracilis tendon. In 19 limbs, the gracilis tendon was harvested according to standard operative routine. The saphenous nerve was subsequently exposed by dissection and injuries were recorded. RESULTS: A well-defined sub-sartorial fascial layer separated the saphenous nerve from the gracilis tendon. Incisional injuries involving either a medial cutaneous crural branch or the infrapatellar branch were found in 14 of the 19 cases. Non-incisional injuries affecting the sartorial branch of the saphenous nerve (to conform to most surgical literature, we use the term 'sartorial branch' to denote the continuation of the saphenous nerve after departure of the infrapatellar branch) were found in six cases located 5-8 cm proximal and posterior to the gracilis tendon insertion on tibia. The fascia separating the saphenous nerve from the gracilis tendon had been perforated in relation to all non-incisional injuries. CONCLUSIONS: Small subcutaneous branches of the saphenous nerve are at risk of injury from the incision, while the sartorial branch is at risk outside the incision area. Descriptions of the location of non-incisional injuries have not been published before and are of clinical relevance, as they can contribute to the prevention of saphenous nerve injuries during gracilis tendon harvest.


Assuntos
Veia Safena/lesões , Tendões/transplante , Coleta de Tecidos e Órgãos/efeitos adversos , Idoso , Idoso de 80 Anos ou mais , Reconstrução do Ligamento Cruzado Anterior/efeitos adversos , Cadáver , Dissecação/efeitos adversos , Fáscia/lesões , Feminino , Músculo Grácil , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Fatores de Risco , Transplante Autólogo
10.
Foot Ankle Surg ; 26(4): 358-362, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31176530

RESUMO

BACKGROUND: The aim of the present systematic literature review is to give an overview of ruptures of the plantar fascia. For this purpose, a detailed description of the patient collective is provided. However, the focus of this analysis is based on the current therapy concepts. Based on the results the authors propose a standardized therapy concept. MATERIAL AND METHODS: A systematic literature review was performed using the PubMed database using the terms: ("rupture plantar fascia" OR "plantar fascia tear" OR "rupture plantar aponeurosis"). All articles published in the PubMed database until 07.11.2018 were included. The articles were evaluated with regard to three research question: (1) Which patients are affected by a rupture of the plantar fascia? (2) Which therapy concept was used to treat rupture of the plantar fascia? And (3) which result was achieved and how was this measured? RESULTS: A total of 78 studies were identified, of which the full text of 17 were analysed. 12 publications were cases reports, 5 studies were retrospective analyses. Data from 124 patients could be included. The average age of patients was 39.6 years. In 63.2% (n = 12) of the studies, patients with a high level of athletic activity or even professional athletes were analyzed. 94.4% of all patients were treated conservatively. The average duration of immobilization in a rigid walker was 2.6 weeks. In the majority of cases, pain-adapted weight-bearing was allowed in the rigid walker. CONCLUSION: There are few available studies concerning the rupture of plantar fascia. The quality of data is poor. The maximum duration of immobilization of 3 weeks in a rigid walker with pain-adapted weight-bearing appears to be the most applied therapy concept. Further studies are needed to evaluate the efficacy of the therapy and to optimize the therapy concept.


Assuntos
Traumatismos do Tornozelo/terapia , Gerenciamento Clínico , Fáscia/lesões , Procedimentos Ortopédicos/normas , Traumatismos do Tornozelo/fisiopatologia , Aponeurose/lesões , Humanos , Imobilização/métodos , Ruptura , Suporte de Carga
11.
J Foot Ankle Surg ; 59(1): 195-200, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31882140

RESUMO

Surgical repair of complete plantar fascia ruptures has not yet been reported in the literature. Operative technique and outcome are described in 2 gymnasts with heavy plyometric demands who received surgical repair compared with 3 athletes treated nonoperatively. Biomechanics and clinical implications are discussed. In the last 8 years, we have seen 5 high-demand athletes with total rupture of the plantar fascia. This is a retrospective clinical evaluation 1.5 to 8 years postinjury of all 5 patients using dynamic ultrasound, Foot Function Index, sports-specific questions, Foot Posture Index, and foot length. The operated gymnasts returned to the same level of performance within 12 months. None of the conservatively treated athletes returned to preinjury plyometric sports levels but reached a foot load capacity of distance running with the injured foot as limiting factor. Ultrasound with simultaneous dorsiflexion of the toes showed a normal fascia in the operated patients, but a slack fascia that tightened up only at terminal toe dorsiflexion in the conservatively treated group. According to the Foot Function Index, the operated patients reported no complaints, whereas the nonoperative group had clinical relevant impairments in activities of daily life. The Foot Posture Index in all nonoperated patients showed a relative shift toward pronation with increased foot length compared with the noninjured foot. The operated patients showed no difference in foot length but minimal shift into supination with a slightly altered arch contour. Surgical repair of plantar fascia ruptures is technically feasible to restore normal foot load capability with return to high-demand plyometric sports within 12 months.


Assuntos
Traumatismos em Atletas/cirurgia , Fáscia/lesões , Traumatismos do Pé/cirurgia , Pé/cirurgia , Antepé Humano/lesões , Antepé Humano/cirurgia , Adulto , Feminino , Traumatismos do Pé/etiologia , Humanos , Masculino , Ruptura , Adulto Jovem
12.
Medicine (Baltimore) ; 98(52): e18428, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31876720

RESUMO

RATIONALE: The plantar fascia (PF) is an important anatomical structure that stabilizes the longitudinal arch of the foot. While plantar fasciitis is a common pathology affecting the foot, tears of the PF are uncommon injuries characterized by acute pain in the plantar aspect of the foot. The main purpose of this paper was to describe, in detail, how the ultrasonographic pattern of PF rupture can be combined with the clinical features to define the prognosis and promptly plan the therapeutic approach. PATIENT CONCERNS: In the first case, a 39-year-old male patient was seen due to acute pain in the mid plantar foot which appeared 3 days after a tennis match. The pain was accompanied by a "snap" noise and intense pain. In the second case, a 44-year-old male patient was seen due to pain in the heel region which appeared 2 days after a running session. DIAGNOSIS: One case of noninsertional complete tear of the central bundle of the PF with retraction of the 2 stumps and 1 case of partial tear of the central bundle of the PF at the level of the insertional region. INTERVENTIONS: Both patients were treated with conservative therapies including load management, oral nonsteroidal anti-inflammatory drugs, foot orthosis, and restriction of sport activities. OUTCOMES: At follow-up, the patient with spontaneous complete tear of the PF (noninsertional area) showed a small fibrous bridge between the 2 stumps, with partial alignment of the proximal and distal portions, the ability to walk for a medium to long-distance, and difficulty going up and downstairs. The patient with the spontaneous partial tear (insertional area) showed complete fibrous scar tissue with restoration of the fascial continuity, and the ability to walk for a long-distance and go up and downstairs without pain. LESSONS: Based on the clinical and ultrasonographic findings, we suggest that partial tear of the PF in the insertional region presents a favorable prognosis with complete recovery, both clinically and anatomically, while a complete tear in the noninsertional region is associated with partial functional and histological recovery when managed with a conservative approach. Therefore, coupling the clinical findings with the sonohistologic pattern is a valuable approach to plan the most suitable treatment for patients with spontaneous PF tear.


Assuntos
Fáscia/lesões , Traumatismos do Pé/terapia , Ruptura/terapia , Adulto , Tratamento Conservador/métodos , Fáscia/diagnóstico por imagem , Traumatismos do Pé/diagnóstico por imagem , Humanos , Masculino , Ruptura/diagnóstico por imagem , Ultrassonografia
13.
Injury ; 50(8): 1429-1432, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31279477

RESUMO

INTRODUCTION: Opioid-related compartment syndrome (ORCS) is an understudied complication related to opioid overdose. We hypothesized that ORCS would be associated with worse clinical outcomes, including higher amputation rates, need for multiple surgical procedures, and rhabdomyolysis on admission, compared with nonopioid-related compartment syndrome (NORCS). METHODS: We used Current Procedural Terminology codes for fasciotomy as a proxy marker for cases of compartment syndrome treated at 1 health system from January 1, 2016, to December 21, 2018. We excluded patients younger than 18 years, those treated for exertional compartment syndrome, and those who underwent elective fasciotomies. Seventy-four patients met our inclusion criteria. Data reviewed included patient characteristics, cause of compartment syndrome, time until evaluation for compartment syndrome, peak creatinine kinase levels, number of surgical procedures required, duration of hospital stay, and postoperative inpatient morbidity and death. Patients were categorized as having ORCS (n = 8) or NORCS (n = 66). Alpha = .05. RESULTS: All cases of ORCS occurred in men. Opioid use was the third most common cause of compartment syndrome. Two patients underwent amputation, both in the ORCS group (p <  0.01). The median number of debridements was significantly higher for the ORCS group (median, 4; interquartile range [IQR]: 3-6) than for the NORCS group (median, 3; IQR 2-4) (p =  0.03). Duration of hospital stay was longer for the ORCS group (median, 27 days; IQR 16-38) compared with the NORCS group (median, 9 days; IQR: 5-13) (p <  0.001). Mean (± standard deviation) peak creatinine kinase level was significantly higher in the ORCS group (224,000 ± 225,052 U/L) compared with the NORCS group (7550 ± 32,500) (p <  0.001). The proportion of patients who underwent hemodialysis was higher in the ORCS group (88%) than in the NORCS group (35%) (p <  0.001). All ORCS patients presented >8 h after immobilization in a dependent position. CONCLUSION: Patients in the ORCS group had delayed presentations and significantly more morbidity compared with patients in the NORCS group.


Assuntos
Síndromes Compartimentais/etiologia , Fáscia/lesões , Dependência de Heroína/complicações , Transtornos Relacionados ao Uso de Opioides/complicações , Insuficiência Renal/epidemiologia , Rabdomiólise/epidemiologia , Lesões do Sistema Vascular/complicações , Adulto , Síndromes Compartimentais/epidemiologia , Síndromes Compartimentais/fisiopatologia , Síndromes Compartimentais/terapia , Fáscia/irrigação sanguínea , Fasciotomia , Feminino , Dependência de Heroína/epidemiologia , Dependência de Heroína/fisiopatologia , Dependência de Heroína/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos Relacionados ao Uso de Opioides/epidemiologia , Transtornos Relacionados ao Uso de Opioides/fisiopatologia , Transtornos Relacionados ao Uso de Opioides/terapia , Estudos Retrospectivos , Estados Unidos/epidemiologia , Lesões do Sistema Vascular/epidemiologia , Lesões do Sistema Vascular/fisiopatologia , Lesões do Sistema Vascular/terapia
15.
Rev Med Liege ; 73(12): 610-614, 2018 Dec.
Artigo em Francês | MEDLINE | ID: mdl-30570231

RESUMO

Morel-Lavallée syndrome is a trauma that remains rare and whose management is not yet standardized. It is a closed delamination between the fascia superficialis and the cutaneous-subcutaneous tissue. This empty space is filled with fluid and may be complicated by surinfection and tissue necrosis. Regularly described in heavy traumatology, it should not be ignored in routine practice. We present the case of a regular leisure athlete with a sus-patellar syndrome of Morel-Lavalée as well as its diagnostic and therapeutic management. The evolution was favorable with a well-conducted conservative treatment. We discuss every step of the possible care in clinical practice to sensitize general practitioners to this pathology.


Le syndrome de Morel-Lavallée est un traumatisme qui reste rare et dont la prise en charge n'est pas encore standardisée. Il s'agit d'un décollement fermé entre le fascia superficialis et le tissu cutané-sous-cutané. Cet espace vide est comblé par du liquide et peut se compliquer par une surinfection et une nécrose tissulaire. Régulièrement décrit dans la traumatologie lourde, il ne faut pas le méconnaître en pratique médicale de ville. Nous présentons le cas d'un sportif de loisir régulier présentant un syndrome de Morel-Lavalée sus-rotulien ainsi que sa prise en charge diagnostique et thérapeutique. L'évolution fût favorable avec un traitement conservateur bien conduit. Nous discutons chaque étape de la prise en charge possible en médecine de ville afin de sensibiliser les praticiens généralistes à cette pathologie.


Assuntos
Avulsões Cutâneas/terapia , Traumatismos do Joelho/terapia , Adulto , Crioterapia , Fáscia/lesões , Humanos , Masculino , Modalidades de Fisioterapia
16.
Br J Sports Med ; 52(23): 1497, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30072398

RESUMO

The fascial system builds a three-dimensional continuum of soft, collagen-containing, loose and dense fibrous connective tissue that permeates the body and enables all body systems to operate in an integrated manner. Injuries to the fascial system cause a significant loss of performance in recreational exercise as well as high-performance sports, and could have a potential role in the development and perpetuation of musculoskeletal disorders, including lower back pain. Fascial tissues deserve more detailed attention in the field of sports medicine. A better understanding of their adaptation dynamics to mechanical loading as well as to biochemical conditions promises valuable improvements in terms of injury prevention, athletic performance and sports-related rehabilitation. This consensus statement reflects the state of knowledge regarding the role of fascial tissues in the discipline of sports medicine. It aims to (1) provide an overview of the contemporary state of knowledge regarding the fascial system from the microlevel (molecular and cellular responses) to the macrolevel (mechanical properties), (2) summarise the responses of the fascial system to altered loading (physical exercise), to injury and other physiological challenges including ageing, (3) outline the methods available to study the fascial system, and (4) highlight the contemporary view of interventions that target fascial tissue in sport and exercise medicine. Advancing this field will require a coordinated effort of researchers and clinicians combining mechanobiology, exercise physiology and improved assessment technologies.


Assuntos
Adaptação Fisiológica , Traumatismos em Atletas/diagnóstico , Fáscia/lesões , Fáscia/fisiologia , Doenças Musculoesqueléticas/diagnóstico , Envelhecimento , Traumatismos em Atletas/prevenção & controle , Desempenho Atlético , Pesquisa Biomédica , Consenso , Exercício Físico/fisiologia , Humanos , Doenças Musculoesqueléticas/prevenção & controle , Esportes/fisiologia , Medicina Esportiva
17.
J Biomech Eng ; 140(10)2018 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-30029246

RESUMO

Recent work utilizing ultrasound imaging demonstrated that individuals with low back pain (LBP) have increased thickness and decreased mobility of the thoracolumbar fascia (TLF), an indication that the TLF may play a role in LBP. This study used a porcine injury model (microsurgically induced local injury)-shown to produce similar results to those observed in humans with LBP-to test the hypothesis that TLF mechanical properties may also be altered in patients with LBP. Perimuscular TLF tissue was harvested from the noninjured side of vertebral level L3-4 in pigs randomized into either control (n = 5) or injured (n = 5) groups. All samples were tested with a displacement-controlled biaxial testing system using the following protocol: cyclic loading/unloading and stress relaxation tests at 25%, 35%, and then 45% of their resting length. Tissue anisotropy was also explored by comparing responses to loading in longitudinal and transverse orientations. Tissues from injured pigs were found to have greater stretch-stretch ratio moduli (measure of tissue stiffness), less energy dissipation, and less stress decay compared to tissues from control pigs. Responses across these variables also depended on loading orientation. CLINICAL SIGNIFICANCE: these findings suggest that a focal TLF injury can produce impairments in tissue mechanical properties away from the injured area itself. This could contribute to some of the functional abnormalities observed in human LBP.


Assuntos
Fáscia/lesões , Vértebras Lombares , Resistência à Tração , Vértebras Torácicas , Animais , Anisotropia , Fenômenos Biomecânicos , Estresse Mecânico , Suínos
18.
J Am Board Fam Med ; 31(2): 282-285, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29535246

RESUMO

Plantar fascia rupture in the absence of previous diagnosis of plantar fasciitis, corticosteroid injection, or injury is a rare occurrence with only 7 case reports in the literature since 1978. This is a case of spontaneous plantar fascia rupture in a 38-year-old active-duty US military member with current considerations in musculoskeletal ultrasound, other radiologic imaging, treatment, and followup of this diagnosis.


Assuntos
Fáscia/lesões , Dor Musculoesquelética/etiologia , Ruptura Espontânea/diagnóstico por imagem , Adulto , Fáscia/diagnóstico por imagem , Humanos , Imobilização/instrumentação , Imageamento por Ressonância Magnética , Masculino , Dor Musculoesquelética/terapia , Dispositivos de Fixação Ortopédica , Ruptura Espontânea/complicações , Ruptura Espontânea/terapia , Ultrassonografia
19.
Radiologia (Engl Ed) ; 60(3): 230-236, 2018.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-29530318

RESUMO

OBJECTIVES: We aim to review the characteristics of Morel-Lavallée lesions and to evaluate their treatment. MATERIAL AND METHODS: We retrospectively reviewed 17 patients (11 men and 6 women; mean age, 56.1 years, range 25-81 years) diagnosed with Morel-Lavallée lesions in two different departments. All patients underwent ultrasonography, 5 underwent computed tomography, and 9 underwent magnetic resonance imaging. Percutaneous treatment with fine-needle aspiration and/or drainage with a 6F-8F catheter was performed in 13 patients. Two patients required percutaneous sclerosis with doxycycline. RESULTS: All patients responded adequately to percutaneous treatment, although it was necessary to repeat the procedure in 4 patients. CONCLUSIONS: Radiologists need to be familiar with this lesion that can be treated percutaneously in the ultrasonography suite when it is not associated with other entities.


Assuntos
Fáscia/diagnóstico por imagem , Fáscia/lesões , Tela Subcutânea/diagnóstico por imagem , Tela Subcutânea/lesões , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Fêmur , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Ferimentos e Lesões/diagnóstico por imagem , Ferimentos e Lesões/terapia
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